Whole slide images (WSIs) are vital in digital pathology, enabling gigapixel tissue analysis across various pathological tasks. While recent advancements in multi-modal large language models (MLLMs) allow multi-task WSI analysis through natural language, they often underperform compared to task-specific models. Collaborative multi-agent systems have emerged as a promising solution to balance versatility and accuracy in healthcare, yet their potential remains underexplored in pathology-specific domains. To address these issues, we propose WSI-Agents, a novel collaborative multi-agent system for multi-modal WSI analysis. WSI-Agents integrates specialized functional agents with robust task allocation and verification mechanisms to enhance both task-specific accuracy and multi-task versatility through three components: (1) a task allocation module assigning tasks to expert agents using a model zoo of patch and WSI level MLLMs, (2) a verification mechanism ensuring accuracy through internal consistency checks and external validation using pathology knowledge bases and domain-specific models, and (3) a summary module synthesizing the final summary with visual interpretation maps. Extensive experiments on multi-modal WSI benchmarks show WSI-Agents's superiority to current WSI MLLMs and medical agent frameworks across diverse tasks.

In this study, we built an end - to - end tumor - infiltrating lymphocytes (TILs) assessment pipeline within QuPath, demonstrating the potential of easily accessible tools to perform complex tasks in a fully automatic fashion. First, we trained a pixel classifie r to segment tumor, tumor - associated stroma, and other tissue compartments in breast cancer H&E - stained whole - slide images (WSI) to isolate tumor - associated stroma for subsequent analysis. Next, we applied a pre - trained StarDist deep learning model in QuPa th for cell detection and used the extracted cell features to train a binary classifier distinguishing TILs from other cells. To evaluate our TILs assessment pipeline, we calculated the TIL density in each WSI and categorized them as low, medium, or high T IL levels. Our pipeline was evaluated against pathologist - assigned TIL scores, achieving a Cohen's kappa of 0.71 on the external test set, corroborating previous research findings. These results confirm that existing software can offer a practical solution for the assessment of TILs in H&E - stained WSIs of breast cancer.

In recent years, sentiment analysis has gained increasing significance, prompting researchers to explore datasets in various languages, including Turkish. However, the limited availability of Turkish datasets has led to their multifaceted usage in different studies, yielding diverse outcomes. To overcome this challenge, a rigorous review was conducted of research articles published between 2012 and 2022. 31 studies were listed, and 23 Turkish datasets obtained from publicly available sources and email requests used in these studies were collected. We labeled these 31 studies using a taxonomy. We provide a map of sentiment analysis datasets according to this taxonomy in Turkish over 10 years. Moreover, we run state-of-the-art sentiment analysis tools on these datasets and analyzed performance across popular Turkish sentiment datasets. We observed that the performance of the sentiment analysis tools significantly depends on the characteristics of the target text. Our study fosters a more nuanced understanding of sentiment analysis in the Turkish language.

Recent advances have enabled the study of human brain development using brain organoids derived from stem cells. Quantifying cellular processes like mitosis in these organoids offers insights into neurodevelopmental disorders, but the manual analysis is time-consuming, and existing datasets lack specific details for brain organoid studies. We introduce BOrg, a dataset designed to study mitotic events in the embryonic development of the brain using confocal microscopy images of brain organoids. BOrg utilizes an efficient annotation pipeline with sparse point annotations and techniques that minimize expert effort, overcoming limitations of standard deep learning approaches on sparse data. We adapt and benchmark state-of-the-art object detection and cell counting models on BOrg for detecting and analyzing mitotic cells across prophase, metaphase, anaphase, and telophase stages. Our results demonstrate these adapted models significantly improve mitosis analysis efficiency and accuracy for brain organoid research compared to existing methods. BOrg facilitates the development of automated tools to quantify statistics like mitosis rates, aiding mechanistic studies of neurodevelopmental processes and disorders. Data and code are available at https://github.com/awaisrauf/borg.

Landslide susceptibility mapping (LSM) is crucial for identifying high-risk areas and informing prevention strategies. This study investigates the interpretability of statistical, machine learning (ML), and deep learning (DL) models in predicting landslide susceptibility. This is achieved by incorporating various relevant interpretation methods and two types of input factors: a comprehensive set of 19 contributing factors that are statistically relevant to landslides, as well as a dedicated set of 9 triggering factors directly associated with triggering landslides. Given that model performance is a crucial metric in LSM, our investigations into interpretability naturally involve assessing and comparing LSM accuracy across different models considered. In our investigation, the convolutional neural network model achieved the highest accuracy (0.8447 with 19 factors; 0.8048 with 9 factors), while Extreme Gradient Boosting and Support Vector Machine also demonstrated strong predictive capabilities, outperforming conventional statistical models. These findings indicate that DL and sophisticated ML algorithms can effectively capture the complex relationships between input factors and landslide occurrence. However, the interpretability of predictions varied among different models, particularly when using the broader set of 19 contributing factors. Explanation methods like SHAP, LIME, and DeepLIFT also led to variations in interpretation results. Using a comprehensive set of 19 contributing factors improved prediction accuracy but introduced complexities and inconsistency in model interpretations. Focusing on a dedicated set of 9 triggering factors sacrificed some predictive power but enhanced interpretability, as evidenced by more consistent key factors identified across various models and alignment with the findings of field investigation reports....

Crowd anomaly detection is one of the most popular topics in computer vision in the context of smart cities. A plethora of deep learning methods have been proposed that generally outperform other machine learning solutions. Our review primarily discusses algorithms that were published in mainstream conferences and journals between 2020 and 2022. We present datasets that are typically used for benchmarking, produce a taxonomy of the developed algorithms, and discuss and compare their performances. Our main findings are that the heterogeneities of pre-trained convolutional models have a negligible impact on crowd video anomaly detection performance. We conclude our discussion with fruitful directions for future research.

Mask-based annotation of medical images, especially for 3D data, is a bottleneck in developing reliable machine learning models. Using minimal-labor user interactions (UIs) to guide the annotation is promising, but challenges remain on best harmonizing the mask prediction with the UIs. To address this, we propose the user-guided domain adaptation (UGDA) framework, which uses prediction-based adversarial domain adaptation (PADA) to model the combined distribution of UIs and mask predictions. The UIs are then used as anchors to guide and align the mask prediction. Importantly, UGDA can both learn from unlabelled data and also model the high-level semantic meaning behind different UIs. We test UGDA on annotating pathological livers using a clinically comprehensive dataset of 927 patient studies. Using only extreme-point UIs, we achieve a mean (worst-case) performance of 96.1% (94.9%), compared to 93.0% (87.0%) for deep extreme points (DEXTR). Furthermore, we also show UGDA can retain this state-of-the-art performance even when only seeing a fraction of available UIs, demonstrating an ability for robust and reliable UI-guided segmentation with extremely minimal labor demands.

This paper presents a novel fuzzy logic based Adaptive Super-twisting Sliding Mode Controller for the control of dynamic uncertain systems. The proposed controller combines the advantages of Second order Sliding Mode Control, Fuzzy Logic Control and Adaptive Control. The reaching conditions, stability and robustness of the system with the proposed controller are guaranteed. In addition, the proposed controller is well suited for simple design and implementation. The effectiveness of the proposed controller over the first order Sliding Mode Fuzzy Logic controller is illustrated by Matlab based simulations performed on a DC-DC Buck converter. Based on this comparison, the proposed controller is shown to obtain the desired transient response without causing chattering and error under steady-state conditions. The proposed controller is able to give robust performance in terms of rejection to input voltage variations and load variations.